• Permeability assessment - Determine permeability on Caco-2 and bovine blood brain barrier models
• P-gp efflux transporter - In vitro evaluation of P-gp (MDR1) substrates & inhibitors (bi-directional transport, uptake/efflux, ATPase)
• Enzyme Inhibition - predicts the potential for compounds to inhibit the metabolism of other drugs and hence risk adverse reactions
• Reaction Phenotyping (enzyme mapping) - used to determine the metabolic pathways involved in biotransformation of compounds
• Species Comparisons - identify the non-human species whose metabolic profile for specific compounds most closely resembles that of man
• Metabolic Stability (turnover) - measure the rate at which compounds are metabolised
• Metabolite Characterization / Identification - determine human-specific metabolites and possible risk of metabolite toxicity
• Hepatotoxicity - measure the result of exposure to a potential toxicant (primary or immortalized hepatocytes)
• Enzyme Induction (in-vitro and ex-vivo) - assess the potential for candidate compounds to up-regulate genes, increase the production of mRNA or protein, or induce enzymatic activity in comparison to each other and to known compounds.
• PrediScreen Service Solutions - Determine drug-transporter interactions. Efflux and uptake transporters.

  If you'd like to find out more about the services we can provide, please do not hesitate to contact us for further information or to request a quotation.