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Self renewal

PD98059
A MEK inhibitor that enhances self-renewel of embryonic stem cells¹.

EI-360
5mg

SB203580
A p38 inhibitor useful for deriving and maintaining embryonic stem cells¹. Increases growth-factor-induced DNA synthesis and mitosis of adult cardiomyocytes consistent with dedifferentiation of these mature cells².

EI-286
1mg
5mg

Neuronal & Hematopoietic STem CELLS

Retinoic Acid, All Trans
Extensively used in neuronal differentiation protocols^3,4.

GR-100
500mg
5g

Lysophosphatidic Acid (LPA)
Induces clonal generation of mouse neurospheres via proliferation of neuronal progenitors positive for sca-1 and AC133, markers of hematopoietic and neural stem cells⁵.

LP-100
5mg
25mg

DAPT - NS-phenyl-glycine-t-butyl ester
A g-secretase inhibitor, which antagonizes Notch signaling through inhibition of Notch processing^6,7. DAPT-treatment can influence hematopoietic cell fate decisions and enhances neuronal differentiation in embryonic stem cell-derived embryoid bodies independent of sonic hedgehog signaling⁸.

PI-154
5mg

Mesenchymal STem CELLS

Dexamethasone
Modulates osteogenesis of mesenchymal stem cells⁹.

EI-126
1g
5g

PPARg agonists - Troglitazone (Cat. # GR-210) & Ciglitazone (Cat. # GR-205)
Thiazolidinediones stimulate adipogenesis and decrease osteoblastogenesis in human mesenchymal stem cells¹⁰.

GR-210 &
GR-205
5 mg
25 mg

Cardiac STem CELLS

Trichostatin A (TSA)
A class I & II HDAC inhibitor. Induces increased acetylation of GATA4, a cardiac-specific transcription factor, and increased cardiac muscle differentiation¹¹.

GR-309
1mg
5 mg

Pancreatic STem CELLS

Cyclopamine
An alkaloid sonic hedgehog pathway inhibitor. Cyclopamine induces expression of pdx-1, a transcription factor essential for pancreas development, b-cell differentiation and insulin secretion, and stimulates insulin secretion in differentiation protocols of mouse embryonic stem cells^12,13.

GR-334
1 mg
5 mg

PI-3 Kinase inhibition
PI-3 kinase inhibition favors differentiation versus proliferation in embryonic stem cells¹⁴. PI-3 kinase inhibitors have also been used in conjunction with nicotinamide to mature mouse embryonic stem cell-derived insulin-producing cells¹⁵.
LY-294002 (Cat. # ST-420) & Wortmannin (Cat. # ST-415)

ST-420
5mg
ST-415
1 mg
5mg